General calculating model of the needs for allogenic stem cell tran­splantation for the patients with leukaemia and myelodysplastic syndrome in Vojvodina

Abstract

Introduction. Allogeneic stem cell transplantation (SCT) application represents a treatment of choice that enables the eradication of malignant clone and chance for remedy of the patients with hematological diseases. Only 30-40% of the potential patients for allogeneic SCT have an HLA identical sibling, due to the fact that families in most of the developed countries are relatively small. Material and methods. This study gives a general model for calculating the needs for allogeneic SCT which, enables calculation of the needs for allogeneic SCT per 1 million inhabitants of Vojvodina on basis of number of potential patients who could be treated by allogeneic SCT. The number of beds required for transplanted patients, and of days in hospital per year as well as the estimation of financial aspect of allogeneic SCT, have been calculated by means of the cummulative risk method, considering the following parameters: the relative number of patients suffering from ANLL, ALL, CML, CLL and MDS, 45 and 55 years old and younger, total incidence/100 000 inhabitants for each investigated disease and the average number of days in hospital of transplanted patients. Results. Total annual needs for allogeneic SCT for the patients suffering from ANLL, ALL, CML, CLL and MDS together, in transplantation with stem cells from their related donors are 786 days, from the unrelated donors are 306 days, while for nonmyeloablative transplantation with stem cells from their related donors are 558 days and from the unrelated ones are 297 days. Conclusion. The general calculating model of the needs for allogeneic SCT could be used as a basis for planning a regional bone marrow donor registry and for creating a similar calculating model of the needs for allogeneic SCT in other diseases treatable by HSCT.