Integral evaluation of thyroid lymphatic region in phytocorrection of hypothyroidism consequences-Reference-Cited by-同舟云学术

Integral evaluation of thyroid lymphatic region in phytocorrection of hypothyroidism consequences

Published:2024-01-10 Issue:6 Volume:43 Page:108-116
ISSN:2410-2520
Container-title:Сибирский научный медицинский журнал
language:
Short-container-title:Sibirskij nauchnyj medicinskij zhurnal

Author:

Gorchakov V. N.¹^ORCID,Nikolaychuk K. M.²^ORCID,Demchenko G. A.³^ORCID,Nurmakhanova B. A.³^ORCID,Gorchakova O. V.²^ORCID

Affiliation:

1. Novosibirsk State University; Research Institute of Clinical and Experimental Lymphology – Branch of the Federal Research Center Institute of Cytology and Genetics SB RAS

2. Novosibirsk State University

3. Institute of Genetics and Physiology of the Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan

Abstract

To date, the integrative involvement of thyroid lymphatic region structures in providing tissue homeostasis in hypothyroidism and during rehabilitation remains a poorly understood problem. The use of phytotherapy is attractive for reducing the effects of hypothyroidism. This issue requires scientific justification during the rehabilitation phase.Material and methods. The work was performed on 160 white Wistar rats using light and electron microscopy according, data of morphometry and statistical matrix analysis. An adequate model of hypothyroidism was created by mercazolil administration. After the mercazolil withdrawal, we investigated the reversibility of thyroid and regional lymph node changes during the rehabilitation period (on 7, 14, 21 days) on the background of bioactive phytocomposition intake and without it. Phytocomposition from laminaria and medicinal plants of Siberia was used at a dose of 0.2 g/kg for three weeks after the cancellation of mercazolil.Results and discussion. The study showed a unidirectional change in thyroid and lymph node structure with a preferential decrease in indicators in hypothyroidism. The value of the total normalized index for the lymphatic region (lymphothyroostat) is negative during the recovery period without phytocorrection. The index has a negative value initially and up to 14 days and becomes positive only by the end of 21 days of the study reflecting the inertia of the structural response of organs. Phytotherapy provides high rationed index rates for lymphothyrostat. The index becomes positive starting at day 14. There is an intensification of compensatory and adaptive reactions at all levels of lymphothyrostat organization, starting with ultrastructural. The lymph node contributes significantly to the provision of homeostasis of the lymph region of the thyroid gland.Conclusions. Reorganization of the lymph node and thyroid gland is interconnected in hypothyroidism. The active role of the lymph node in providing tissue homeostasis in the lymph region of the thyroid is apparent. Thyroid and lymph node function can be enhanced by phytotherapy. Phytocomposition reduces the effects of hypothyroidism. It is a kind of modifier of thyroid and lymph node structure and function

Publisher

Institute of Cytology and Genetics, SB RAS

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