Affiliation:
1. Federal Research Center of Fundamental and Translational Medicine
Abstract
The presence of infectious inflammatory process in a pregnant woman can lead to a disorder in the “mother – placenta – fetus” system.Aim of the study was to investigate the level of regulatory and pro-inflammatory molecules in pregnancy occurring against the background of chronic pyelonephritis without exacerbation.Material and methods. The concentration of IL-17A, monocytic chemotactic protein-1 (MCP-1), vascular endothelial growth factor (VEGF), and IgG autoantibodies to double-stranded DNA (AAT to nDNA) was determined in the blood serum of pregnant women with a gestation period of 36–40 weeks using ELISA.Results. It has been shown that in the third trimester of pregnancy occurring against the background of chronic pyelonephritis without exacerbation, compared with a normal pregnancy, the level of MHP-1 and IL-17A increases, the content of VEGF decreases, and the concentration of AAT to nDNA does not change significantly. An increase in the proinflammatory cytokine IL17A and a decrease in VEGF level can lead to intrauterine fetal growth retardation due to inhibition of amino acid transporters in the placenta.Conclusions. In pregnancy occurring against the background of chronic pyelonephritis without exacerbation, a change in the level of IL17A, MСP-1, VEGF can have a significant impact on the course of pregnancy.
Publisher
Institute of Cytology and Genetics, SB RAS
Reference16 articles.
1. Shcherbakov V.I., Ryabichenko T.I., Skosyreva G.A., Trunov A.N. Spectrum of anti- inflammatory cytokines in pregnant women with placental insufficiency and fetal growth retardation. Rossiyskiy vestnik akushera-ginekologa = Russian Bulletin of Obstetrician-Gynecologist. 2019;19(3):11–16. [InRussian]. doi: 10.17116/rosakush20191903111
2. Sidorova I.S., Babina M.G. Specific features of systemic and local immunodeficiency in pregnant women with exacerbation of chronic pyelonephritis. Rossiyskiy vestnik akushera-ginekologa = Russian Bulletin of Obstetrician-Gynecologist. 2002;2(6):27–30. [In Russian].
3. Luppi P., Haluszczak C., Trucco M., Deloia I.A. Normal pregnancy is associated with peripheral leukocyte activation. Am. J. Reprod. Immunol. 2002;47(2):72– 81. doi: 10.1034/j.1600-0897.2002.1o041.x
4. Forger F., Vallbracht I., Helmke K., Villiger P.M., Østengen M. Pregnаncy mediated improvement of rheumatoid arthritis. Swis. Med. Wely. 2012;142:w13644. doi: 10.4414/smw.2012.13644
5. Harnish D.C. Estrogen receptor, ligands in the control of pathogenic inflammation. Curr. Opin. Investig. Drugs. 2006;7(11):997–1001.