Affiliation:
1. Stavropol State Medical University of Minzdrav of Russia
2. Stavropol Regional Clinical Hospital
Abstract
The aim of the study was to investigate the lipid status and indicators of the system of hemostasis in healthy young men of different linguistic families of the North Caucasus region to assess the risk of development of thrombogenic states.. Material and methods. A survey of young men aged 18 to 21 years was carried out with the subsequent establishment of region of residence and nationality to form ethnic groups. Based on the information received during the survey, 62 people were selected: 32 young men of the Indo-European language family (Russians, Greeks, Armenians) and 30 young men of the North Caucasian language family (Chechens, Ingush, Avars, Dargins). The assessment of lipid status was carried out by the photocolorimetric method on a biochemical analyzer, and the analysis of indicators of the hemostasis system was carried out by the clotting method on an automatic coagulometer analyzer. Homocysteine levels were determined by chemiluminescent immunoassay on a microplate device. Genetic polymorphisms of the hemostatic system were identified using the real-time PCR. Results. Young men of the Indo-European language family have significantly more low density lipoprotein, triglyceride, homocysteine and antithrombine III content, than representatives of the North Caucasian language family (p < 0.001), and less total number and average platelet volume, prothrombin index, prothrombin concentration according to Quick (p < 0.001). There was also a significantly more frequent occurrence of mutations of the gene encoding fibrinase (p < 0.05) in young men of the Indo-European language family. Conclusions. A comprehensive study among young men of different ethnicities illustrates ethnic differences in lipid status and homocysteine level. Analysis of the main indicators of coagulogram and genetic polymorphism of the hemostasis system allowed us to establish a higher risk of thrombogenic conditions and atherosclerosis in young men of the North Caucasian language family
Publisher
Institute of Cytology and Genetics, SB RAS
Reference13 articles.
1. Byshevsky A.Sh., Karpova I.A., Fomina I.V., Khvoshchina T.N., Dron A.N., Chernova A.M., Kiyanyuk N.S., Tarasov D.B. Hemocoagulation and lipid peroxidation in women taking sex steroids with ethinyl estradiol and the progestogen drospirenone. Vestnik Yuzhno-Ural’skogo gosudarstvennogo universiteta. Seriya: Obrazovaniye, zdravookhraneniye, fizicheskaya kul’tura = Bulletin of the South Ural State University. Series: Education, healthcare, physical education. 2012;(28):52–57. [In Russian].
2. Marventano S., Kolacz P., Castellano S., Galvano F., Buscemi S., Mistretta A., Grosso G. A review of recent evidence in human studies of n-3 and n-6 PUFA intake on cardiovascular disease, cancer, and depressive disorders: does the ratio really matter? Int. J. Food Sci. Nutr. 2015;66(6):611–622. doi: 10.3109/09637486.2015.1077790
3. Paganelli F., Mottola G., Fromonot J., Marlinge M., Deharo P., Guieu R., Ruf J. Hyperhomocysteinemia and cardiovascular disease: is the adenosinergic system the missing link? Int. J. Mol. Sci. 2021;22(4):1690. doi: 10.3390/ijms22041690
4. Abduganieva E.A. The role of homocysteine as a pathogenetic factor in the development of thrombophilic conditions. Sibirskoe meditsinskoe obozrenie = Siberian Medical Review. 2023;(2):8–16. [In Russian]. doi: 10.20333/25000136-2023-2-8-16
5. Langer H.F., Bigalke B., Seizer P., Stellos K., Fateh-Moghadam S., Gawaz M. Interaction of platelets and inflammatory endothelium in the development and progression of coronary artery disease. Semin. Thromb. Hemost. 2010;36(2):131–138. doi: 10.1055/s-0030-1251496