FARKLI ÇÖZÜCÜLERİN TÜRKİYE`DE YETİŞEN CİSTUS CRETICUS EKSTRAKLARININ KİMYASAL KOMPOZİSYON, ANTİOKSİDAN AKTİVİTE VE ANTİMİKROBİYAL POTANSİYELİNE ETKİSİ

Abstract

The aims of this study were (1) to assess the extract yield, antioxidant activity, and antimicrobial activity of Cistus creticus extracts obtained from different locations in Türkiye (2) to evaluate the effect of water and methanol solvents on chemical composition, total polyphenol and flavonoid content, IC50, and FRAP values of C. creticus. The extracts had a weak inhibitory effect against tested microorganisms. However, the results of antioxidant assays were very promising. The IC50 values of methanol and water extracts were 13.94 µg/mL and 34.41 µg/mL, respectively. Similarly, the FRAP value of methanolic extract (1.27 M/g) was higher than the water extract (0.72 M/g). The results of HPLC analysis demonstrated that rutin was found only in the methanol extract (13.252%). In addition, the methanol extract had a higher content of quercetin (7.909%), benzoic acid (4.226%), and chlorogenic acid (2.168%), whereas the water extract possessed a higher amount of gallic acid (13.705%).