Complexation equilibria of ambroxol hydrochloride in solution by potentiometric and conductometric methods

Author:

Naggar Ahmed Hosny1ORCID,Al-Saidi Hammed Mohammed2ORCID,Farghaly Othman Abd El-Moaty1ORCID,Hassan Taher Mohammed3ORCID,Bortata Salma Zaidan Mohamed3ORCID

Affiliation:

1. Chemistry Department, Faculty of Science, Al-Azhar University, Assiut Branch, 71524, Assiut, Egypt

2. Department of Chemistry, University College in Al-Jamoum, Umm Al-Qura University, 21955, Makkah, Kingdom of Saudi

3. Chemistry Department, Faculty of Science, Sebha University, Sebha, Libya

Abstract

The formation constants of Li(I), Mg(II), Sr(II), Ca(II), Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Ba(II), Pb(II), Al(III), Cr(III), Fe(III) and Th(IV) ions with ambroxol hydrochloride (AMB) were calculated using the half-n value. In presence of 0.1 M NaNO3, metal ions such as Zn(II), Cd(II), Ni(II), Cr(III), Li(I), Mg(II) and Al(III) forms three types of metal-ligand complexes (1:1, 1:2 and/or 1:3), while Sr(II) and Co(II) tend to form two types of metal complexes 1:1 and 1:2 (M:L). For ligand protonation constants, two logarithmic association constant values were calculated by the half-n method and are 10.7 and 7.6, respectively. The effect of ionic strength on stability constant of AMP, with different metal ions viz. Fe(III), Th(IV), Al(III), Cr(III) and Cu(II) was studied. Based on relationship between the ionic strength studied values and the 1st stability constants (Log K1H), we can conclude that the stability constants of the formed metal-ligand complex (1:1) were decreased as the ionic strength increased. The stoichiometry of the formed complexes in solution were determined by conductometric method and it is found to be of 1:1, 1:2 and/or 1:3 (M:L) complex species is formed in alkaline media. Also, study the species distribution diagrams of AMP for the calculated mole fraction αML and αML2 were discussed.

Publisher

European Journal of Chemistry

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