A mild and efficient method for the deprotection of trimethyl silyl alkynes using sodium ascorbate and copper sulphate-Reference-Cited by-同舟云学术

A mild and efficient method for the deprotection of trimethyl silyl alkynes using sodium ascorbate and copper sulphate

Published:2018-12-31 Issue:4 Volume:9 Page:317-321
ISSN:2153-2257
Container-title:European Journal of Chemistry
language:en
Short-container-title:Eur J Chem

Author:

Siddaraj Ranjith¹^ORCID,Ningegowda Raghu¹^ORCID,Shivananju Nanjunda Swamy²^ORCID,Priya Babu Shubha¹^ORCID

Affiliation:

1. Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India

2. Department of Biotechnology, Sri Jayachamarajendra College of Engineering, JSS Technical Institutions Campus, Mysore 570006, Karnataka, India

Abstract

A competent and fast method for the deprotection of trimethyl silyl group was attained by using cheap, easily accessible, and nontoxic sodium ascorbate in combination with copper sulphate. The method labored was simple and effective for the cleavage of trimethyl silyl group from the protected trimethyl silyl alkynes to their corresponding alkyne derivatives. Wide functional group tolerance, shorter time period, simple procedure and high yields are the striking features of this protocol.

Publisher

European Journal of Chemistry

Link

http://www.eurjchem.com/index.php/eurjchem/article/viewFile/1729/pdf_1729

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