Affiliation:
1. Department of Chemistry, University of North Bengal, Darjeeling, 734013, India
Abstract
Hydrazine functionalized Schiff base, 1,2-di(benzylidene)hydrazine has been synthesized through a condensation between hydrazine and benzaldehyde under reflux, and structurally characterized. The crystal structure analysis reveals that the Schiff base crystallizes in an orthorhombic crystal system with the Pbcn space group. Crystal data for C14H12N2: a = 13.130(2) Å, b = 11.801(2) Å, c = 7.5649(16) Å, V = 1172.1(4) Å3, Z = 4, T = 298.0(2) K, μ(MoKα) = 0.071 mm-1, Dcalc = 1.180 g/cm3, 10252 reflections measured (6.206° ≤ 2Θ ≤ 65.352°), 2027 unique (Rint = 0.0381, Rsigma = 0.0283) which were used in all calculations. The final R1 was 0.0627 (I > 2σ(I)) and wR2 was 0.2462 (all data). It is evident that the imine protons are intramolecularly locked with the imine-N bond, and the phenyl rings exist in anti orientation with respect to the =N-N= bond adopting a nearly planar conformation. The Schiff base grows a one-dimensional framework in the crystalline phase through long-distant C-H···π interaction. Hirshfeld surface and energy framework analyses have also been performed to understand the supramolecular forces and their contributions meticulously. The hydrazine functionalized Schiff base showed an excellent antidiabetic activity through α-amylase inhibitory assay relative to a standard compound, acarbose under an identical condition.
Publisher
European Journal of Chemistry
Reference45 articles.
1. [1]. Jucker, E. Recent pharmaceutical research on hydrazine derivatives. Pure Appl. Chem. 1963, 6, 409-434.
2. [2]. Toki, T.; Koyanagi, T.; Yoshida, K.; Yamamoto, K.; Morita, M. Hydrazine compounds usesful as pesticides. 5304657, April 19, 1994.
3. [3]. Butufei, O.; Mazare, M.; Deaconescu, I.; Rolea, G.; Pascu, C.; Nicolescu, I. V. Polymer Catalysts. J. Macromol. Sci. - Chem. 1985, 22, 889-895.
4. [4]. Parravano, G. Polymerization induced by catalytic decomposition of hydrazine at palladium surfaces. J. Am. Chem. Soc. 1950, 72, 3856-3860.
5. [5]. Evans, D. D.; Price, T. W. The status of monopropellant hydrazine technology, JPL Technical Report 1968, 32-722. https://ntrs.nasa.gov /api/citations/19680006875/downloads/19680006875.pdf (accessed April 10, 2022).
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献