ACUTE TOXICITY OF THE VETERINARY MEDICINAL PRODUCT BASED ON MELOXICAM

Abstract

Laboratory studies were conducted to determine the acute and subacute toxicity of the veterinary drug "Loksidev" (solution for injections) on white rats, white mice, rabbits and dogs. The drug "Loksidev" (solution for injections) belongs to non-steroidal antiinflammatory drugs and is used to treat animals with diseases: European fallow deer, deer - inflammatory processes of the musculoskeletal system (traumatic edema, arthritis, arthrosis, bursitis, tendinitis, etc.), acute respiratory infections, purulent catarrhal mastitis (in combination with antibiotic therapy); sports horses - acute and chronic inflammatorydiseases of the musculoskeletal system (traumatic edema, arthritis, arthrosis, bursitis, tendinitis, tendovaginitis, laminitis, pododermatitis, purulent-inflammatory hoof lesions (in combination with antibacterial agents), colic.According to the results of determining the parameters of the acute toxicity of the drug "Loksidev" (solution for injections) in the case of a single intragastric administration, the LD50 for female rats (based on the absolute weight of the drug) is 6375,93±494,70 mg/kg of body weight, which allows in terms of toxicity, it can be classified as class V - practically non-toxic substances (LD50 5001-15000 mg/kg of body weight), and according to the degree of danger, it can be classified as class IV – low-hazard substances (LD50>5000 mg/kg of body weight).According to the results of determining the parameters of the acute toxicity of the drug "Loksidev" (solution for injections) in the case of a single subcutaneous injection, the LD50 for female rats (based on the absolute weight of the drug) is 4702,52±469,16 mg/kg, and for male mice 4849,01±531,24 mg/kg of body weight, which makes it possible to assign it to the VI class - relatively non-harmful substances (LD 50Subcut >4500 mg/kg of body weight).