A Novel Fragment Recommendation Workflow using Direct and Indirect Transfer of SAR According to Integrated Similarities of Scaffold Motifs and SAR Trends: Application to Identifying Factor Xa Inhibitors-Reference-Cited by-同舟云学术

A Novel Fragment Recommendation Workflow using Direct and Indirect Transfer of SAR According to Integrated Similarities of Scaffold Motifs and SAR Trends: Application to Identifying Factor Xa Inhibitors

Published:2017 Issue:0 Volume:17 Page:1-18
ISSN:1347-0442
Container-title:Chem-Bio Informatics Journal
language:en
Short-container-title:CBIJ

Author:

Ishihara Tsukasa¹,Mori Kenichi¹,Munakata Ryosuke¹,Moritomo Ayako¹

Affiliation:

1. Medicinal Chemistry Research Labs., Drug Discovery Research, Astellas Pharma Inc.

Publisher

Chem-Bio Informatics Society

Subject

Biochemistry

Link

https://www.jstage.jst.go.jp/article/cbij/17/0/17_1/_pdf

Reference40 articles.

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2. [2] Pinto, D. J. P.; Smallheer, J. M.; Cheney, D. L.; Knabb, R. M.; Wexler, R. R. Factor Xa Inhibitors: Next-Generation Antithrombotic Agents. J. Med. Chem. 2010, 53, 6243-6274.

3. [3] Herron, D. K.; Goodson, T., Jr.; Wiley, M. R.; Weir, L. C.; Kyle, J. A. et al. 1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa. J. Med. Chem. 2000, 43, 859-872.

4. [4] Yee, Y. K.; Tebbe, A. L.; Linebarger, J. H.; Beight, D. W.; Craft, T. J. et al. N ²-Aroylanthranilamide Inhibitors of Human Factor Xa. J. Med. Chem. 2000, 43, 873-882.

5. [5] Masters, J. J.; Franciskovich, J. B.; Tinsley, J. M.; Campbell, C.; Campbell, J. B. et al. Non-Amidine-Containing 1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa with Potent Anticoagulant and Antithrombotic Activity. J. Med. Chem. 2000, 43, 2087-2092.