Molecular modeling study of the thymidine phosphorylase inhibitor by SBDD and classical QSAR analysis-Reference-Cited by-同舟云学术

Molecular modeling study of the thymidine phosphorylase inhibitor by SBDD and classical QSAR analysis

Published:2017 Issue:0 Volume:17 Page:19-29
ISSN:1347-0442
Container-title:Chem-Bio Informatics Journal
language:en
Short-container-title:CBIJ

Author:

Tada Yukio¹,Kazuno Hideki²,Sato Tsutomu²,Suzuki Norihiko²,Emura Tomohiro²,Yano Shingo³

Affiliation:

1. Department of Computational Intelligence and System Science, Tokyo Institute of Technology

2. Tsukuba Research Center, Taiho Pharmaceutical Co., Ltd.

3. CMC Center, Taiho Pharmaceutical Co., Ltd.

Publisher

Chem-Bio Informatics Society

Subject

Biochemistry

Link

https://www.jstage.jst.go.jp/article/cbij/17/0/17_19/_pdf

Reference33 articles.

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2. [2] Suzuki, N.; Emura, T.; Fukushima, M. Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes. Int. J. Oncol. 2011, 39, 263-270.

3. [3] Nakayama, C.; Wataya, Y.; Meyer, R. B.; Santi, D. V.; Saneyoshi, M. et al. Thymidine phosphorylase. Substrate specificity for 5-substituted 2'-deoxyuridines. J. Med. Chem. 1980, 23, 962-964.

4. [4] Ansfield, F. J.; Ramirez, G. Phase I and II studies of 2'-deoxy-5-(trifluoromethyl)-uridine (NSC-75520). Cancer Chemother. Rep. 1971, 55, 205-208.

5. [5] Dexter, D. L.; Wolberg, W. H.; Ansfield, F. J.; Helson. L.; Heiderberger, C. The clinical pharmacology of 5-trifluoromethyl-2'-deoxyuridine. Cancer Res. Org. 1972, 32, 247-253.

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