Author:
Beutler Ulrich,Mazacek Jan,Penn Gerhard,Schenkel Berthold,Wasmuth Daniel
Abstract
An efficient process for the production of terbinafine is described. Starting from (E)-I,3-dichloropropene, neohexene, and N-methyl-( I-naphthylmethyl)amine and using a palladium-catalyzed coupling methodology, terbinafine is produced exclusively as (E)-isomer in a convergent manner. The new process avoids the very toxic and nasty starting materials acrolein and phosphorus pentachloride used in the old process.
Subject
General Medicine,General Chemistry
Cited by
3 articles.
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