Author:
Matsubara Seijiro,Ishibashi Kenichi,Maung Gone Yi Thaw,Morota Yuudai,Umemura Tomomi,Kato Yumi
Abstract
Metal-catalyzed H/D exchange in hydrothermal deuterium oxide, performed in an autoclave using external heating or in a sealed glass tube under microwave irradiation, was shown to be an efficient method for preparing various deuterium-labeled compounds. Phosphonium salts for the Wittig
reaction were deuterated at the ?-position in the presence of MS 4A under microwave irradiation; primary alcohols and primary/secondary amines were deuterated at the ?-position in the presence of ruthenium catalyst under microwave irradiation; metal-catalyzed direct C–H functionalizations
on sp3 and sp2 carbon gave the corresponding fully deuterated products under hydrothermal conditions. These methods gave various deuterium-labelled compounds efficiently using D2O as a D-atom source.
Subject
General Medicine,General Chemistry
Cited by
4 articles.
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