Author:
Dalling Andrew G.,Bower John F.
Abstract
This review concentrates on recent developments from our laboratory concerning the Rh-catalyzed carbonylative C–C bond activation of cyclopropanes. Specifically, we have found that N-based directing groups are effective at controlling the regioselectivity of C–C bond activation
during the formation of rhodacyclopentanone intermediates. These engage tethered ?-unsaturated components (e.g. alkenes) or conventional nucleophiles in cycloaddition and heterocyclization processes, respectively. Using this approach, direct and modular access to a wide range
of complex heterocyclic ring systems is achieved. The review summarizes the scope of our methodologies and outlines key mechanistic features.
Subject
General Medicine,General Chemistry
Cited by
12 articles.
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