Abstract
Macrocyclization methodologies allowing access to macrocycles having an endo aryl ether and an endo aryl–aryl bond, especially those based on an intramolecular SNAr reaction and the Suzuki-Miyaura reaction, are summarized. Total synthesis of complestatin,
a bis-macrocyclic natural product, featuring these two technologies are presented.
Subject
General Medicine,General Chemistry
Cited by
12 articles.
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