Author:
Nguyen Anh,Vessières Anne,Hillard Elizabeth A.,Top Siden,Pigeon Pascal,Jaouen Gérard
Abstract
Depending on the presence or absence of the estrogen receptor in the cells, breast cancer today is often treated by endocrine therapy (tamoxifen) or chemotherapy, respectively. We present now a new paradigm for breast cancer treatment, taking advantage of concepts in bioorganometallic
chemistry. In this way, we have synthesized molecules containing an organometallic moiety (ferrocene), and a biovector (hydroxytamoxifen), yielding compounds which display a new therapeutic spectrum consisting of antiestrogenicity and cytotoxicity. A structure–activity relationship study
has shown that a ferrocene group, linked to a para-phenol group by a conjugated spacer, is a necessary motif for strong cytotoxic effects to be observed.
Subject
General Medicine,General Chemistry
Cited by
161 articles.
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