Author:
Gerber-Lemaire Sandrine,Juillerat-Jeanneret Lucienne
Abstract
Changes in the glycosylation pattern of cellular glycoproteins constitute a hallmark in human cancer and influence tumor progression, suggesting that inhibitors of selected glycosidases may control cancer progression. Following the studies on swainsonine, a natural inhibitor of Golgi
?-mannosidase II, which highlighted the inhibition of cellular mannosidases as a potential innovative approach for the treatment of cancer, several dihydroxylated pyrrolidines and analogues were developed as new potent inhibitors of ?-mannosidases II able to induce antiproliferative
effects in human cancer cells.
Subject
General Medicine,General Chemistry
Cited by
16 articles.
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