Author:
Bommarius Andreas S.,Schwarm Michael,Drauz Karlheinz
Abstract
Five common biocatalytic process platforms for the production of enantiomerically pure amino acids are compared along four different dimensions of merit: i) enantioselectivity, ii) overall yield, iii) biocatalyst operating stability, and iv) reactor space-time yield. All processes practiced
on industrial scale utilize biocatalysts of very high enantioselectivity. Short efficient process routes are a necessity, giving an inherent advantage to routes based on lyase reactions or reduction of prochiral keto acids. For processes based on the splitting of a racemate, recycling the
unwanted enantiomer is crucial. The pKa value of abstracting the ?-proton serves as a first indication of the difficulty of achieving overall yields far in excess of 50% through dynamic resolution. High solubility of substrates and products was found to favor high reactor productivity
(space-time-yield s.t.y. > 1 kg/(I·d)) and high biocatalyst productivity (enzyme consumption number e.c.n. < 500–1000 U/kg of product).
Subject
General Medicine,General Chemistry
Cited by
3 articles.
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