Author:
Buettelmann Bernd,Alanine Alexander,Bourson Anne,Gill Ramanjit,Heitz Marie-Paule,Mutel Vincent,Pinard Emmanuel,Trube Gerhard,Wyler René
Abstract
A series of 2-styryl-pyridines and 2-(3,4-dihydro-naphthalen-2-yl)-pyridines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. The SAR developed in this series resulted in the discovery of high affinity antagonists that are selective (vs. ?1
and M1 receptors) and are active in vivo .
Subject
General Medicine,General Chemistry
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献