Anterior Cranial Base Morphology in Mice with Midfacial Retrusion

Author:

Lozanoff Scott1,Jureczek Stefan1,Feng Tracey1,Padwal Raj12

Affiliation:

1. Departments of Anatomy and Oral Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

2. College of Medicine, University of Saskatchewan. Supported by MRC-MA-10269 (SL) and the Saskatchewan Health Research Board (SJ).

Abstract

The role of the anterior cranial base in the morphogenesis of class III malocclusions remains uncertain. This study was conducted to determine whether morphologic deficiencies occur in the anterior cranial base in the Brachyrrhine (Br) mouse mutant showing severe midfacial retrusion, which is characteristic of a class III malocclusion. Crania from three groups of C3H/Hej, 3H1 Br/+, and 3H1+/+ mice, each consisting of 15 animals, were collected at 1, 3, and 5 days of age (total = 135). The anterior cranial base from each specimen was subjected to computerized reconstruction and ten landmarks were digitized from each model. The landmark configurations were compared using Procrustes analysis. Significant differences between models were determined at each age. In order to localize differences between forms, average landmark configurations derived from Procrustes analysis were subjected to finite-element analysis. Size-change values for the 3H1 Br/+ animals showed magnitudes that increased in an anteroposterior direction when compared to the 3H1 +/+ and C3H/Hej animals at all ages. The largest values were located posteriorly along the ossifying front of the presphenoid. In five of six comparisons, the size-change values separated into two distinct clusters. The posterior region of the anterior cranial base was divisible into two subclusters, one located superiorly and the other interiorly. These data suggest that midfacial retrusion in the Br mouse may be caused, in part, by growth deficiencies in the posterior region of the anterior cranial base, particularly the presphenoidal and sphenoethmoidal regions.

Publisher

SAGE Publications

Subject

Otorhinolaryngology,Oral Surgery

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