Gamma Delta T Cells and Organ Transplantation: A Review of Recent Studies

Abstract

Gamma delta (γδ) T cells have gained a lot of attention in the field of cancer immunotherapy due to their unique innate and adaptive immune properties. However, until recently, their potential significance in organ transplantation went unnoticed. This review highlights the effector roles and potential advantages of γδ T cells in organ transplantation by examining recent studies examining the connection between T cells and organ transplantation. Recent studies have shown that high γδ T-cell immune reconstitution following organ transplantation is associated with a significantly greater overall survival rate and a lower incidence of acute graft-versus-host disease (GVHD), despite prior studies' contradictory findings. These results suggest that γδ T cells might be a useful addition to the current transplantation procedures. The effector activities of γδ T cells and their putative modes of action following organ transplantation will be covered in this review. We also provide a summary of the most recent research on the connection between γδ T cells and organ transplant outcomes, such as acute GVHD and graft survival. Finally, we point out the areas that still need to be studied in order to fully comprehend how γδ T cells function after organ donation.