Vitamin D, VDR and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients

Abstract

Aim: The main purpose of this study is to investigate whether there is any relationship between vitamin D level and anti-inflammatory cytokine profile in fibromyalgia syndrome (FMS) patients. Materials and Methods: 30 FMS diagnosed and 25 healthy female individuals were included in the study. The diagnosis of FMS was made based on the 2010 American College of Rheumatology (ACR) criteria. Vitamin D, vitamin D receptor (VDR), vitamin D binding protein (VDBP) levels and anti-inflammatory cytokine (IL-4, IL-10, TGF-β) levels in the serum of patients and healthy controls were determined using enzyme-linked immunosorbent assay (ELISA). Results: Vitamin D, VDR and VDBP levels were found to be lower in FMS patients than in healthy individuals (p