Effect of experimental fascioliasis on the protein synthesis function of cow liver

Abstract

The purpose of the work was to explore the indicators of functional state and function of protein synthesis of the cow liver within experimental fasciolysis, sensitized to atypical mycobacteria. Ten cows of black-and-white breed were selected for the experiments. Two groups consisting of five animals each were formed. The control group cows were clinically healthy. The animals of the experimental group were contaminated with mycobacteriosis and fascicular invasion. In the course of research, the rules for performing zootechnical experiments on the selection and maintenance of animal-analogues in the group, harvesting technology, use and accounting of consumed feed were followed. Being impacted by fascicular invasion, the cattle sensitized with mycobacteria demonstrated the suppression of the liver protein synthesis function, which manifests itself as a decrease in total blood protein, a decrease in the level of albumins and an increase in the level of globulins. According to the clinical manifestation of fasciolosis in the cattle sensitized with atypical mycobacteria, disease pathogens have a toxic effect on hepatocytes causing an increase in the permeability of the biological membranes of the cell membranes. The indicated changes lead to an increase in the activity of blood serum enzymes, in particular, aminotransferases (AsAT and AlAT) and alkaline phosphatase. High activity of AlAT and AsAT in the blood serum of the cows under experimental fasciolysis sensitized by atypical mycobacteria, indicates destructive processes in the liver that cause release of aminotransaminases from cellular organelles in the blood of the cattle. Thus, the results obtained indicate an increase in destructive processes in the body of the cows under experimental fascioliasis sensitized with atypical mycobacteria.