АНТИМІКРОБНА АКТИВНІСТЬ ЕТАНОЛЬНОГО ЕКСТРАКТУ SERRATULA CORONATA L. (ASTERACEAE) ЗА ІНТРОДУКЦІЇ В ЖИТОМИРСЬКОМУ ПОЛІССІ

Abstract

<p> Antimicrobial properties of <em>Serratula coronata </em>L<em>., </em>introduced in Zhytomyr Polissya, were studied against test cultures of <em>Escherichia coli</em> (coliform bacillus) UCM B-906 (ATCC 25922), <em>Staphylococcus aureus</em>(golden staphylococcus) UCM B-904 (ATCC 25923), <em>Pseudomonas aeruginosa</em> (blue pus bacillus) UCM B-900 (ATCC9027), <em>Candida albicans</em> UCM Y-(ATCC 885-653).</p><p><em>Serratula coronata </em>L.<em> </em>40 % ethanol extract showed potent antimicrobial effect against gram-positive bacteria <em>Staphylococcus aureus</em>. Compared with the solvent, MIC (minimal inhibitory concentration) and MBC (minimal bactericidal concentration) increased 32 and 8 times, respectively. The other microorganisms’ cultures demonstrated much lower sensitivity. The study revealed less significant effect of the extract against <em>Candida albicans, Pseudomonas aeruginosa, </em>and it failed to display any bactericidal/fungicidal effect against gram-negative strains of <em>Escherichia coli, Pseudomonas aeruginosa </em>and fungus <em>Candida albicans.</em>The data obtained experimentally show that further study of <em>Serratula coronata </em>L<em>. </em>and its application as the basis for new pharmaceutical anti-staphylococcus preparations may be considered promising and having a great potential.</p>