Зв’язок функціональної активності клітин-попередників кісткового мозку при хронічній мієлоїдній лейкемії з індивідуальною відповіддю на терапію

Abstract

The paper presents an effective method of the monitoring of individual response of the patients with chronic myeloid leukemia (CML) to the therapy with tyrosine kinase inhibitors (TKi). The growth patterns analysis of hematopoietic cells from CML patients showed that functional activity of bone marrow progenitor cells of the patients with complete response to TKi therapy was significantly lower (p < 0.05) in comparison with the colony-forming efficiency of bone marrow sampled from patients with a resistance to the therapy. The correlations were revealed between numbers of colony-forming units and the percentage of Ph+ cells in the bone marrow. This correlation was positive for the group of patients who were alternatively treated with the hydroxyurea and negative for the group of individuals with the resistance to TKi therapy.