Wollfian tumor: a case report and a literature review

Abstract

Wolffian tumor is a rare neoplasm arising from mesonephric duct remnants. Not more than 100 cases of the disease have been described. The authors present their own clinical observation of the Wolffian tumor in a 43-year old female patient. Radiological examinations resulted in the suspicion of a subserous leiomyoma of the uterus; however, the surgery showed a mass arising from the fallopian tube wall. Histologically, there was a growing tumor within the fallopian tube wall with no mucosal lesions. The tumor consisted of myxomatous stroma with cribriform, solid and reticular areas composed of relatively monomorphic, mildly eosinophilic cells with monotonous nuclei and single mitoses. On immunohistochemistry, the tumor cells expressed vimentin, pan-cytokeratin, cytokeratin 7 and calretinin. This case illustrates that final verification and differential diagnosis of the tumor with other fallopian tube neoplasms, including malignancies, is only possible with an immunohistochemical study.