Cytoplasmic ABCG2 and Podoplanin Expression in Oral Squamous Cell Carcinoma Correlates with Lymph Node Metastasis

Author:

Liu Han1,Xia Shilin2,Zhu Lei1,Li Nan1,Yang Qian1,Dong Yan1,Nakano Keisuke3,Nagatsuka Hitoshi3,Xiao Jing1

Affiliation:

1. Department of Oral Pathology, Dalian Medical University

2. Clinical Laboratory of Integrative Medicine, the First Affiliated Hospital of Dalian Medical University

3. Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

Publisher

Society for Hard Tissue Regenerative Biology

Subject

Cell Biology,General Dentistry,Orthopedics and Sports Medicine,Biomaterials,Biochemistry,Medicine (miscellaneous)

Reference21 articles.

1. 1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136: E359-386, 2015

2. 2. Kim M, Turnquist H, Jackson J, Sgagias M, Yan Y, Gong M, Dean M, Sharp JG and Cowan K. The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells. Clin Cancer Res 8: 22-28,2002

3. 3. Tsunoda S, Okumura T, Ito T, Kondo K, Ortiz C, Tanaka E, Watanabe G, Itami A, Sakai Y and Shimada Y. ABCG2 expression is an independent unfavorable prognostic factor in esophageal squamous cell carcinoma. Oncology 71: 251-258, 2006

4. 4. Kaneko MK, Kato Y, Kitano T and Osawa M. Conservation of a platelet activating domain of Aggrus/podoplanin as a platelet aggregation-inducing factor. Gene 378: 52-57, 2006

5. 5. Neri S, Ishii G, Taira T, Hishida T, Yoshida J, Nishimura M, Nagai K and Ochiai A. Recruitment of podoplanin positive cancer-associated fibroblasts in metastatic lymph nodes predicts poor prognosis in pathological N2 stage III lung adenocarcinoma. Ann Surg Oncol 19: 3953-3962, 2012

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