Lipopolysaccharide and High Concentrations of Glucose Enhances Zoledronate-induced Increase in RANKL/OPG Ratio by Upregulating PGE2 Production in Osteoblasts

Author:

Nagasaki Maki1,Nakai Kumiko23,Tanaka Hideki23,Ozaki Manami23,Kato Kengo1,Koshi Ryosuke2,Maeno Masao4,Nishikubo Shuichi56,Kawato Takayuki23,Tonogi Morio56

Affiliation:

1. Nihon University Graduate School of Dentistry

2. Department of Oral Health Sciences, Nihon University School of Dentistry

3. Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry

4. Nihon University

5. Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry

6. Division of Oral Structural and Functional Biology, Nihon University School of Dentistry

Publisher

Society for Hard Tissue Regenerative Biology

Subject

Cell Biology,General Dentistry,Orthopedics and Sports Medicine,Biomaterials,Biochemistry,Medicine (miscellaneous)

Reference43 articles.

1. 1. Zhang J, Wang R, Zhao YL, Sun XH, Zhao HX, Tan L, Chen DC and Hai-Bin X. Efficacy of intravenous zoledronic acid in the prevention and treatment of osteoporosis: a meta-analysis. Asian Pac J Trop Med 5(9): 743-748, 2012

2. 2. Russell RG and Rogers MJ. Bisphosphonates: from the laboratory to the clinic and back again. Bone 25: 97-106, 1999

3. 3. Schmidt A, Rutledge SJ, Endo N, Opas EE, Tanaka H, Wesolowski G, Leu CT, Huang Z, Ramachandaran C, Rodan SB and Rodan GA. Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate. Proc Natl Acad Sci USA 93(7): 3068-3073, 1996

4. 4. Otero JE, Stevens JW, Malandra AE, Fredericks DC, Odgren PR, Buckwalter JA and Morcuende J. Osteoclast inhibition impairs chondrosarcoma growth and bone destruction. J Orthop Res 32(12): 1562-1571, 2014

5. 5. Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 61(9): 1115-1117, 2003

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