SOLVENT FREE SYNTHESIS OF CHALCONE AS ANTIBACTERIAL SUBSTANCE
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Published:2017-04-08
Issue:1
Volume:13
Page:95
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ISSN:2443-4183
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Container-title:ALCHEMY Jurnal Penelitian Kimia
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language:
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Short-container-title:ALCHEMY J.Pen.Kim
Author:
Prabawati Susy Yunita,Khusnuryani Arifah,Khamidinal Khamidinal
Abstract
<p>The aims of this study was to synthesize a compound of 3-methoxy-4-hydroxychalcone through Claisen-Schmidt condensation with grinding technique (solvent-free). Vanillin, acetophenone and 60 % NaOH catalyst used in this synthesis. Characterization of products was done with a spectrophotometer FTIR and <sup>1</sup>H-NMR spectrometer. The product was obtained as a orange solid which has a melting point at 58 - 59 ˚C. Identification of the product by IR spectrophotometer showed the absorption of C=C in the wavenumber of 1496.76 cm<sup>-1</sup> which confirmed that the hydration reaction of chalcone had occurred. Analysis using <sup>1</sup>H-NMR spectrometer also showed the proton of the CH=CH appearing on chemical shift (δ) 7.99 ppm. The antibacterial activity test showed that the compounds of 3-methoxy-4- hydroxychalcone has a potential as an antibacterial against bacteria <em>E. coli</em> and <em>B. subtilis</em>.</p>
Publisher
Universitas Sebelas Maret
Cited by
1 articles.
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