Prediction and Characterization of CYP3A4-mediated Metabolisms of Azole Fungicides: an Application of the Fused-grid Template* system-Reference-Cited by-同舟云学术

Prediction and Characterization of CYP3A4-mediated Metabolisms of Azole Fungicides: an Application of the Fused-grid Template* system

Published:2020 Issue:2 Volume:8 Page:34-51
ISSN:2187-8404
Container-title:Food Safety
language:en
Short-container-title:Food Safety

Author:

Yamazoe Yasushi¹²,Yamada Takashi²,Nagata Kiyoshi³

Affiliation:

1. Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-ku, Sendai 980-8578, Japan

2. Division of Risk Assessment, National Institute of Health Sciences, Tonomachi 3-25-26, Kawasaki-ku, Kawasaki 210-9501, Japan

3. Department of Environmental Health Science, Faculty of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan

Publisher

Food Safety Commission, Cabinet Office

Link

https://www.jstage.jst.go.jp/article/foodsafetyfscj/8/2/8_D-20-00010/_pdf

Reference72 articles.

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2. 2. Trösken ER, Scholz K, Lutz RW, Völkel W, Zarn JA, Lutz WK. Comparative assessment of the inhibition of recombinant human CYP19 (aromatase) by azoles used in agriculture and as drugs for humans. Endocr Res. 2004; 30(3): 387–394. PMID:15554355, DOI:10.1081/ERC-200035093

3. 3. Mast N, Zheng W, Stout CD, Pikuleva IA. Antifungal azoles: Structural insights into undesired tight binding cholesterol-metabolizing CYP46A1. Molecul Pharmacol. 2013; 84(1): 86–94. PMID:23604141, DOI:10.1124/mol.113.085902

4. 4. Schwartz EL, Hallam S, Gallagher RE, Wiernik PH. Inhibition of all-trans-retinoic acid metabolism by fluconazole in vitro and in patients with acute promyelocytic leukemia. Biochem Pharmacol. 1995; 50(7): 923–928. PMID:7575674, DOI:10.1016/0006-2952(95)00213-J

5. 5. Van Wauwe JP, Coene MC, Goossens J, Van Nijen G, Cools W, Lauwers W. Ketoconazole inhibits the in vitro and in vivo metabolism of all-trans-retinoic acid. J Pharmacol Exp Ther. 1988; 245(2): 718–722. PMID:3367313

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