THE ROLE OF INDIVIDUAL NEUROINFLAMMATION MOLECULES IN PATHOGENESIS ISCHEMIC STROKE. PART I

Abstract

Ischemic stroke is an acute, severe vascular pathology of the brain, accompanied by general cerebral and focal neurological symptoms. The occurrence of the disease is based on arterial thrombosis, leading to the formation of a focus of infarction of brain tissue. In most cases, after an acute cerebral accident, persistent neurological deficits persist in the form of motor, cognitive and other disorders. Cerebral infarction is a multifactorial disease with a complex multicascade pathogenesis. The severity of the disease, the speed of patient recovery and outcome do not always correlate with their age and the presence of underlying pathology. Therefore, at the moment, there is a certain interest in an in-depth study of the pathological processes that occur directly at the site of cerebral infarction and in the penumbra zone (ischemic penumbra). It is possible that a more detailed understanding of the ongoing pathological processes will allow us to further achieve better results in the process of treatment and recovery of patients.The presented literature review highlights current data on the main pathological processes that occur during ischemic stroke. The role of microglia as the main regulator of the processes of inflammation, immunosuppression, degeneration and repair of nervous tissue is considered.