1. a Brunel Institute for Bioengineering, Brunel University , Uxbridge , UB8 3PH , UK
2. b Dept of Biochemical Engineering , UCL Advanced Centre for Biochemical Engineering , Torrington Place, London , WC1E 7JE , UK
3. c Chemistry Department , University of Wales Swansea , Singleton Park, Swansea , SA2 8PP , UK
4. d University of Pau , ENSGTI, Rue Jules Ferny, Pau , 64000 , France
5. e Medicines Research Centre , Glaxo Wellcome, Bioprocessing Unit, Stevenage , UK