Second Generation of cycloSal‐Pronucleotides with Esterase‐Cleavable Sites: The ”Lock‐In”‐Concept
Author:
Affiliation:
1. a Institute of Organic Chemistry , University of Hamburg , Martin‐Luther‐King‐Platz 6, D‐20146, Hamburg, Germany
2. b Rega‐Institute for Medical Research , K.U. Leuven, Minderbroedersstraat 10, B‐3000, Leuven, Belgium
Publisher
Informa UK Limited
Subject
Genetics,Molecular Medicine,Biochemistry,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1081/NCN-120027820
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1. cycloSal-Pronucleotides - Design of Chemical Trojan Horses
2. Cyclosaligenyl-2′,3′-didehydro-2′,3′-dideoxythymidine Monophosphate: Efficient Intracellular Delivery of d4TMP
3. Intracellular Metabolism ofCycloSaligenyl 3′-Azido-2′,3′-dideoxythymidine Monophosphate, a Prodrug of 3′-Azido-2′,3′-dideoxythymidine (Zidovudine)
4. Anti-retrovirus activity of 3′-fluoro- and 3′-azido-substituted pyrimidine 2′,3′-dideoxynucleoside analogues
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