Regenerative endodontics: vary of scaffolds and its benefits for pediatric dentistry

Abstract

Background. Regenerative Endodontic Procedures deliver a suitable environment to promote natural regeneration/repair with a functional pulp–dentin wall and apical closure. However, REPs have a number of features that can complicate their implementation, especially for children. One of them is scaffold formation. Objective. To describe alternative scaffold formation options for pulp revitalization and compare their effectiveness and describe possible causes of periapical tissues not bleeding during endodontic regenerative procedures. Materials and methods. A comprehensive search strategy was done through PubMed and Cochrane Library databases by using MESH terms equivalent to the keywords.  Review articles for the last 5 years were selected according to the keywords with exclusion criteria.  Results. According to the search criteria and keywords, 801 articles were obtained, after applying the exclusion criteria, 11 ones that met the selection requirements were left. Conclusions. The main method of scaffold obtaining is the blood clot formation. However, if it is not possible to make the periapical tissues bleed for clot formation, then the use of platelet-enriched autologous plasma or platelet-rich fibrin is recommended. This technique has proven to be as effective as the main one. It can prevent painfulness caused by bleeding provoking for blood clot formation.