The Correlation between Depression during Pregnancy and Metabolic Syndrome

Abstract

Background: In recent years, the incidence of depression during pregnancy has gradually increased, and the disorder of lipid metabolism in patients with depression is an important research direction. Therefore, this study aimed to explore the correlation between depression during pregnancy and metabolic syndrome (MS).  Methods: A total of 113 pregnant women diagnosed as depression during pregnancy from November 2019 to January 2022 were selected as the observation group. After excluding 3 cases, 110 cases were finally included. And 102 pregnant women who were not diagnosed as depression during pregnancy in the same period were selected as the control group. After excluding 2 cases, 100 cases were finally included for comparative study. The levels of various parameters, including serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG), C-reactive protein (CRP), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were compared between the two groups. Furthermore, the Edinburgh Postnatal Depression Scale (EPDS) was used to evaluate the depression scores of postpartum women. Additionally, the correlation between EPDS scores and clinical indexes was assessed in patients with depression during pregnancy.  Results: We observed that the body weight, EPDS score, the proportion of hyperglycemia, hypertension, and dyslipidemia were significantly higher in the observation group compared to the control group (p < 0.001). Furthermore, the observation group exhibited significantly higher levels of TG, TC, HDL-C, LDL-C, FPG, CRP, SBP, and DBP than the control group (p < 0.001). Pearson linear correlation analysis revealed that TG, TC, HDL-C, LDL-C, FPG, CRP, SBP, and DBP levels were positively correlated with EPDS scores (p < 0.001).  Conclusion: This study indicates a specific correlation between MS and depression during pregnancy, and MS-related indicators are positively correlated with EPDS scores among these individuals.