Abstract
Cluster headache is characterized by pain in the first division of trigeminal nerve along with autonomic features, with attacks last from 15 minutes to 180, up to eight times a day. Albeit considered as a primary headache, it may be mimicked by structural diseases like infections, inflammatory, tumoral and vascular. Intranasal and sinus infectious were also reported. Herpes simplex infections are quite common in the general population, and the nerve ganglia are the natural reservoir of the virus. Intranasal herpes, on the other hand, is exceedingly rare, with only few cases reported in the literature. Our main objective is to describe a case report of a 49-year-old male who was diagnosed with intranasal herpes infection during a bout of cluster headache, evaluated by an otolaryngologist. He got free of symptoms after using valacyclovir and melatonin. Thus, herpes simplex might be involved in the mechanisms of secondary or primary cluster headache. Further research is necessary to help elucidate this relationship.