Formulation and Evaluation of Pulsatile Drug Delivery System of Dexlansoprazole

Abstract

Background: A pulsatile drug delivery system is intended to deliver drugs according to the circadian rhythm, or disease cycle. PDDS prepared by pulsincap technology contain a cross-linked hard gelatin capsule filled with the optimized immediate-release tablet, sodium alginate beads. Dexlansoprazole is used to treat the signs and symptoms of gastroesophageal reflux disease (GERD), erosive esophagitis, and stomach ulcers. Objective: The objective of the research is to develop and analyse a controlled-release pulsatile medication delivery system for the treatment of peptic ulcers that contains dexlansoprazole. Method: The Pulsincap system consists of a hard gelatin capsule containing an immediate-release tablet prepared by direct compression, sodium alginate beads prepared by the ionotropic gelatin method, and a hydrogel plug made through direct compression. The hydrogel plug was prepared by using various grades of HPMC polymer. The immediate-release tablet was prepared by direct compression. Result: The results of the present FTIR studies concluded that there was no interaction between dexlansoprazole and the excipient. Based on the evaluation parameter, it was found that the F2 tablet (1:2) ratio and 2% sodium alginate beads showed better results. Polymer HPMC K15M for Hydrogel showed the desired swelling time. Conclusion: It was concluded that the preparation of a pulsatile drug delivery system for dexlansoprazole through pulsincap technology can give drug release in a pulsed manner that is first immediate release, lag time, and sustain action.