Formulation and Evaluation of Terbinafine Hydro-chloride Loaded Microsponges Gel

Abstract

Background: Microsponges are porous, polymeric microspheres employed for sustained topical treatment. They may modify the release pattern, lessen adverse effects, and improve stability. Terbinafine HCL is a fungicidal allylamine derivative with a wide range of antifungal activity. It is used to treat various skin disorders like ringworm, athlete’s foot, and jock itch. Objective: The aim of the current study focuses on the development of terbinafine HCL microsponges that will release the drug in a sustained pattern to prevent side effects and then put those microsponges into a gel. Method: The quasi-emulsion solvent diffusion method was employed to develop Microsponges by using various drug: polymer ratios. Result: The results of the FTIR spectra showed that there was an absence of interaction between Terbinafine HCL and the excipients. Based on the evaluation parameter, it was found that batch MS3 showed the highest entrapment efficiency of 86.32%. Polymer EC showed better results. Microsponges and Microsponges gel showed sustained release of drug till 8 and 10 hours, respectively. The gels were shown to be stable throughout a wide temperature range, according to the stability studies. Conclusion: It was concluded that the Microsponges release the drug in a stained manner. The production process for microsponge technology has the potential to improve patient compliance with terbinafine hydrochloride microsponge gel.