Nanosuspensions: A Promising Drug Delivery Systems

Abstract

One of the critical problems associated with poorly soluble drugs is low bioavailability and or erratic absorption. The problem is even more complex for drugs such as itraconazole and Carbamazepine (belonging to BCS CLASS II) as they are poorly soluble in both aqueous and organic media, and for those drugs having a log P value of 2. There are number of formulation approaches to resolve the problems of low solubility and low bioavailability. But all those have some limitations and hence have limited utility in solubility enhancement. Nanotechnology can be used to resolve these problems associated with conventional approaches. Nanotechnology is defined as the science and engineering carried out in the nanoscale that is 10-9 meters. Nanosuspensions consist of the pure poorly water-soluble drug without any matrix material suspended in dispersion. A nanosuspension not only solves the problems of poor solubility and bioavailability but also alters the pharmacokinetics of drug and thus improves drug safety and efficacy