Effect of ambulation following 18F-fluorodeoxyglucose injection on standing positron emission tomography of the healthy equine digit

Author:

Oliver Andrea1,Wulster Kathryn1,Stefanovski Darko1,Spriet Mathieu2,Ciamillo Sarah1,Ford Mathew1,Kulp Jeaneen1,van Eps Andrew1

Affiliation:

1. Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA

2. Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA

Abstract

Abstract OBJECTIVE Measure 18F-FDG uptake in digital tissues of healthy horses subjected to different ambulatory conditions between the time of injection and positron emission tomography (PET) scan acquisition. ANIMALS 8 healthy adult horses. METHODS Horses were walked (AMB) or tied in stalls (NONAMB) immediately after injection with ∼1.5 MBq/kg 18F-FDG until scan acquisition using a randomized crossover design. Steps were quantified using accelerometers. Standardized uptake values (SUV; mean and maximum) in digital tissues including the dorsal lamellae (proximal, middle, and distal), quarter lamellae (medial and lateral), and coronary band were analyzed using a mixed-effects linear regression model. RESULTS Mean (95% CI) step count for AMB (569[484–653]) was higher than NONAMB (88[24–152]) P = <.001. The SUVmax (but not SUVmean) was increased in AMB compared with NONAMB in the proximal (2.74[2.52–2.98] vs 2.42[2.05–2.78]; P = .04) and middle (2.74[2.37–3.11] vs 2.36[2.05–2.68]; P = .03) dorsal lamellae but was not different in the distal lamellae or coronary band. In the medial quarter lamellae, both SUVmax (2.53[1.58–3.48] vs 2.07[0.81–3.33]; P = .01) and SUVmean (1.90[1.55–2.25] vs 1.49[0.91–2.06]; P = .007) were increased in AMB compared with NONAMB. The medial quarter lamellae also had lower SUVmax (P = .002) and SUVmean (P = .04) compared with the lateral quarter and lower SUVmax compared with the mid-dorsal lamellae (P = .01). CLINICAL RELEVANCE Lamellar 18F-FDG uptake was affected by ambulatory activity mostly in the medial quarter; however, this effect was relatively small and unlikely to interfere with clinical detection of laminitis.

Publisher

American Veterinary Medical Association (AVMA)

Subject

General Veterinary,General Medicine

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