Measuring tissue oxygen saturation in the orad intestinal segment during equine colic surgery may aid in predicting the occurrence of postoperative ileus

Author:

Verhaar Nicole1,Grages Anna Marei1,Sauer Fay J.1,Geiger Tobias1,Reineking Wencke2,Hewicker-Trautwein Marion2,Geburek Florian1,Kästner Sabine B.R.13

Affiliation:

1. Clinic for Horses, University of Veterinary Medicine Hannover, Hannover, Germany

2. Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany

3. Clinic for Small Animals, University of Veterinary Medicine Hannover, Hannover, Germany

Abstract

Abstract OBJECTIVE To assess the histological injury and intestinal microperfusion measured by laser Doppler flowmetry and spectrophotometry (LDFS) of the small intestine orad to a strangulation during colic surgery. ANIMALS Horses with naturally occurring small intestinal strangulations undergoing colic surgery were included. METHODS In this prospective clinical trial, intestinal tissue oxygen saturation (tSO2) and tissue blood flow (tBF) were measured by LDFS orad to the strangulation following release of the strangulation (n = 18). The number of horses with postoperative reflux (POR) and the cases that survived until discharge were compared between groups using Fisher’s exact test (P < .05). Intestinal biopsies were taken in cases that underwent intestinal resection or intraoperative euthanasia (n = 28). Measurements were compared between injured and noninjured segments with a Mann-Whitney U or t test. RESULTS The tSO2 and tBF of the orad intestine were lower than previously reported in healthy horses. Horses with low tSO2 of < 35% were significantly more likely to suffer from POR (6/6 cases) compared to cases with tSO2 > 69% (1/6). The number of horses that survived were not statistically different between these groups (2/6 and 6/6). All horses with mucosal injury developed POR (6/6), which was significantly more likely compared to horses without mucosal injury (3/13). No significant difference in tSO2 or tBF could be found between the segments with and without histological injury. CLINICAL RELEVANCE The results suggest that measuring tSO2 in the orad segment during colic surgery may aid in predicting postoperative issues.

Publisher

American Veterinary Medical Association (AVMA)

Reference35 articles.

1. The characteristics of intestinal injury peripheral to strangulating obstruction lesions in the equine small intestine;Gerard M,1999

2. Effect of lidocaine on in ammation in equine jejunum subjected to manipulation only and remote to intestinal segments subjected to ischemia;Bauck AG,2017

3. Morphological data indicate a stress response at the oral border of strangulated small intestine in horses;De Ceulaer K,2011

4. Histologic findings in the gastrointestinal tract of horses with colic;Meschter C,1986

5. Use of quantitative real-time PCR to determine the local inflammatory response in the intestinal mucosa and muscularis of horses undergoing small intestinal resection;Lisowski ZM,2022

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3