Affiliation:
1. Department of Veterinary Medicine, Universidade Castelo Branco, Rio de Janeiro, RJ, Brazil
2. Department of Veterinary Medicine and Surgery, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, Brazil
Abstract
Abstract
OBJECTIVE
To evaluate the anesthetic and cardiopulmonary effects of ketamine–dexmedetomidine combined with local anesthesia, associated or not in the postoperative period with different doses of atipamezole, for orchiectomy in cats.
ANIMALS
24 healthy cats.
PROCEDURES
Cats received ketamine (7 mg/kg) combined with dexmedetomidine (10 µg/kg) IM, and 1 mL of saline (group KDSAL), 25 µg/kg (group KDAT25), or 50 µg/kg (group KDAT50) of atipamezole IV, postoperatively. All cats received local anesthesia (2 mg/kg of lidocaine) intratesticular and SC. Physiologic variables were recorded at baseline and at time points during anesthesia. Ketamine rescue dose (1 mg/kg) was recorded. The quality of recovery, the degree of sedation, and side effects were evaluated postoperatively.
RESULTS
2 cats received a single additional bolus of ketamine to perform local anesthesia. Heart rate was lower in KDSAL, KDAT25, and KDAT50 during anesthesia, compared with baseline. Hypertension was observed intraoperatively in all groups. The time to head up, pedal reflex regained time, time to sternal recumbency, and time to standing were shorter in KDAT25 and KDAT50 compared to KDSAL. Lower sedation scores were assigned sooner to KDAT25 and KDAT50 than KDSAL. All groups resulted in low recovery quality scores and no side effects.
CLINICAL RELEVANCE
At the doses used, ketamine–dexmedetomidine combined with local anesthesia allowed the performance of orchiectomy. Rescue dose of ketamine for performing local anesthesia may be required. This combination can result in hypertension. Both atipamezole doses shortened the anesthetic recovery, without differences among them, and side effects.
Publisher
American Veterinary Medical Association (AVMA)
Reference22 articles.
1. Gonadectomy in cats and dogs: a review of risks and benefits;Reichler IM,2009
2. Evaluation of dexmedetomidine and ketamine in combination with various opioids as injectable anesthetic combinations for castration in cats;Ko JC,2011
3. Anaesthetic, analgesic and cardiorespiratory effects of intramuscular medetomidine-ketamine combination alone or with morphine or tramadol for orchiectomy in cats;Zeiler GE,2014
4. Effects of dissociative anesthesia opioid-free protocols combined with local anesthesia, with or without flumazenil or atipamezole postoperatively, for orchiectomy in cats;Gomes VH,2022
5. Anesthetic and analgesic effects of an opioid-free, injectable protocol in cats undergoing ovariohysterectomy: a prospective, blinded, randomized clinical trial;Diep TN,2020