Affiliation:
1. Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX
2. Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX
3. Research Computing Support, University of Tennessee, Knoxville, TN
4. Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC
5. Department of Clinical Science and Services, Royal Veterinary College, University of London, London, UK
Abstract
Abstract
OBJECTIVE
To characterize gastrointestinal transit times (GITTs) and pH in dogs, and to compare to data recently described for cats.
ANIMALS
7 healthy, colony-housed Beagles.
PROCEDURES
The GITTs and pH were measured using a continuous pH monitoring system. For the first period (prefeeding), food was withheld for 20 hours followed by pH capsule administration. Five hours after capsule administration, dogs were offered 75% of their historical daily caloric intake for 1 hour. For the second period (postfeeding), food was withheld for 24 hours. Dogs were allowed 1 hour to eat, followed by capsule administration. Both periods were repeated 3 times. The GITTs and pH were compared to published feline data.
RESULTS
The mean ± SD transit times in dogs for the pre- and postfeeding periods, respectively, were esophageal, 3 ± 5 minutes and 13 ± 37 minutes; gastric, 31 ± 60 minutes and 829 ± 249 minutes; and intestinal, 795 ± 444 minutes and 830 ± 368 minutes. The mean ± SD gastrointestinal pH in dogs for the pre- and postfeeding periods, respectively, were esophageal, 6.6 ± 0.6 and 5.7 ± 1.0; gastric, 3.0 ± 1.4 and 1.8 ± 0.3; intestinal, 7.9 ± 0.3 and 7.7 ± 0.6; first-hour small intestinal, 7.6 ± 0.5 and 7.1 ± 0.4; and last-hour large intestinal, 7.9 ± 0.6 and 7.7 ± 1.0. The first-hour small intestinal pH and total transit times varied between dogs and cats depending on feed period (P = .002 and P = .04, respectively). Post hoc analysis revealed significantly shorter total transit times in dogs prefeeding (P = .005; mean ± SD for cats, 2,441 ± 1,359 minutes; for dogs, 828 ± 439 minutes) and postfeeding (P = .03; mean ± SD for cats, 3,009 ± 1,220 minutes; for dogs, 1,671 ± 513 minutes). Total transit time for dogs was also shorter pre- versus postfeeding (P = .003).
CLINICAL RELEVANCE
GITT is faster in Beagles compared to cats, but gastrointestinal pH are similar when fed the same diet.
Publisher
American Veterinary Medical Association (AVMA)
Cited by
2 articles.
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