Implicatons of Metal Complexes in Biology and Medicine the System Cadmium (II)/ Iron (II)/ Zinc (II)-Hydroxyproline

Abstract

The importance of metal ions to essential functions of living systems and for the well being of living organisms is known. Metal ions are fundamental elements for the maintenance of the life spans of the human, animals and plants. The stability constants of Cd2+, Fe2+ and Zn2+ complexes with hydroxyproline were determined by Paper Electrophoretic Technique (PET). This method is based on the movement of a spot of metal ion in an electric field at various pH of background electrolyte. A graph of pH against mobility gives information about the formation of binary complexes and permit to calculate their stability constants. The stability constant of the ML and ML2 complexes of Cd (II) – hydroxyproline, Fe (II) – hydroxyproline and Zn (II) – hydroxyproline, have been found to be (4.41 ± 0.01; 2.95 ± 0.06) (4.11 ± 0.01; 2.81 ± 0.11 and (4.83 ± 0.02; 3.28 ± 0.07) ( logarithm stability constant values), respectively at ionic strength 0.1 mole L-1 (per chloric acid as background electrolyte) and a temperature of 35 0C, The first and second stability constants of metal complexes follow the order Zn (II) > Cd (II) > Fe (II). Metal complexes can offer their action such as anti-inflammatory, antibiotic, anti-thyroid and anticancer compounds. Metal based drugs bioactivity can be increased by metal chelation, which in turn increase their absorbance and stability. Recent advances in inorganic chemistry have made possible formation of a number of metal complexes with organic ligands of interest which can be use as therapeutic agents.