Protective Effect of Coenzyme Q10 in Children with Heart Failure

Abstract

Background: Heart failure is considered a health problem caused by its high mortality, morbidity and high costs of care. The causes of Heart Failure in children differ from that of adults, with the most frequent causes in children being congenital heart disease and cardiomyopathy. Coenzyme Q10 acts as an energy transfer molecule, occurring in organs with high metabolic levels, such as the heart, kidneys and liver. Methodology: A narrative review was carried out through various databases from January 2005 to January 2021; the search and selection of articles was carried out in journals indexed in English. The following keywords were used: Coenzyme Q10, children, Heart Failure, Pediatrics. Results: Supplementation with Coenzyme Q10 has beneficial effects on different etiological variants of heart failure in children, thanks to the prevention of oxidative damage to the defective myocardium, as well as the increase in bioenergetics and its strong antioxidant properties, provided by its important role as an electron carrier in the transport chain. Conclusion: This review offers recommendations to use Coenzyme Q10 as a complementary treatment in Heart Failure in different etiological variants.