Mechanistic modelling of tyrosine recombination reveals key parameters determining the performance of a CAR T cell switching circuit-Reference-Cited by-同舟云学术

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Mechanistic modelling of tyrosine recombination reveals key parameters determining the performance of a CAR T cell switching circuit

Published:2020-03 Issue:1 Volume:4 Page:10-19
ISSN:2398-6182
Container-title:Engineering Biology
language:en
Short-container-title:Eng. biol.

Author:

Bowyer Jack E.¹²,Chakravarti Deboki³⁴,Wong Wilson W.³⁴,Bates Declan G.¹²

Affiliation:

1. School of Engineering University of Warwick Coventry CV4 7AL UK

2. Warwick Integrative Synthetic Biology Centre Coventry CV4 7AL UK

3. Department of Biomedical Engineering Boston University Boston MA 02215 USA

4. Biological Design Center Boston University Boston MA 02215 USA

Funder

Biotechnology and Biological Sciences Research Council

Publisher

Institution of Engineering and Technology (IET)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1049/enb.2019.0020

Reference53 articles.

1. Efficacy and toxicity management of 19‐28z CAR T cell therapy in B cell acute lymphoblastic leukemia;Davila M.L.;Sci. Transl. Med.,2014

2. Safety and persistence of adoptively transferred autologous CD19‐targeted T cells in patients with relapsed or chemotherapy refractory B‐cell leukemias;Brentjens R.J.;Blood,2011

3. Chimeric antigen receptor T cells for sustained remissions in leukemia;Maude S.L.;N. Engl. J. Med.,2014

4. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose‐escalation trial;Lee D.W.;Lancet,2015

5. Remote control of therapeutic T cells through a small molecule‐gated chimeric receptor;Wu C.Y.;Science,2015

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