Affiliation:
1. School of Materials Science and Engineering Key Lab of Advanced Technologies of Materials Ministry of Education Southwest Jiaotong University Chengdu Sichuan China
2. Key Laboratory of Marine Drugs Ministry of Education School of Medicine and Pharmaceutics Ocean University of China Qingdao Shandong China
3. Institute of Biomedical Engineering College of Medicine Southwest Jiaotong University Chengdu Sichuan China
Abstract
AbstractSelenium (Se), a well‐known essential element in human health, plays a vital role in regulating metabolism owing to its antioxidative nature. However, organic Se compounds are toxic and cannot be used for biomedical applications. Selenium nanoparticles (SeNPs) exhibit low biological toxicity and high bioavailability; however, they are prone to aggregation and are extremely unstable, thereby diminishing their bioactivity and bioavailability. To overcome these limitations, ultra‐small, highly stable, and bioactive SeNPs were synthesised based on an in‐situ hybridisation strategy by using polyphenol‐grafted‐chitosan (GA‐CS) to control and restrict crystal growth of Se nanoparticles. The resultant GA‐CS@nSe exhibited an average particle size of ∼30 nm and was highly stable in aqueous solutions. In addition, GA‐CS@nSe displayed improved biocompatibility and enhanced antioxidative activity. Taken together, the authors provide a basis for polyphenol‐mediated construction of Se‐based particles with increased bioactivity.
Funder
Central University Basic Research Fund of China
Basic and Applied Basic Research Foundation of Guangdong Province
Publisher
Institution of Engineering and Technology (IET)
Subject
Surfaces, Coatings and Films,Mechanical Engineering,Biomedical Engineering,Biomaterials,Biophysics