On the role of autophagy in the progression of differentiated thyroid cancer (literature review)-Reference-Cited by-同舟云学术

On the role of autophagy in the progression of differentiated thyroid cancer (literature review)

Published:2022-01-13 Issue:6 Volume:20 Page:134-140
ISSN:2312-3168
Container-title:Siberian journal of oncology
language:
Short-container-title:Sib. onkol. ž.

Author:

Garipov K. A.¹^ORCID,Afanaseva Z. A.¹^ORCID,Abramova Z. I.²^ORCID

Affiliation:

1. Kazan State Medical Academy – branch of the Russian Medical Academy of Continuing Professional Education; Republican Clinical Cancer Center of Ministry of Health of the Republic of Tatarstan

2. Federal University Kazan (Volga Region) Federal University, Institute of Fundamental Medicine and Biology

Abstract

The aim of the study was to analyze and summarize available literature data on the role of autophagy in thyroid cancer. Material and methods. We analyzed 34 publications available from pubmed and elibrary. Ru databases concerning thyroid cancer and autophagy. Results. The review discussed the role of autophagy in the progression of thyroid cancer. The development of autophagy-targeted therapy was shown can improve treatment for thyroid cancer. Differentiated thyroid cancer (dtc) is the most common endocrine malignancy. Treatment of dtc patients who are resistant to radioactive iodine therapy is a major challenge. Molecular targeted therapy using tyrosine kinase inhibitors significantly improves treatment outcomes. Conclusion. To enhance the therapeutic effect of treatment with multi-target tyrosine kinase inhibitors, as well as to overcome drug resistance, it is necessary to study the role of autophagy in the development and progression of thyroid cancer.

Publisher

Tomsk Cancer Research Institute

Subject

Cancer Research,Oncology

Reference34 articles.

1. Borodavina E.V., Isaev P.A., Shurinov A.Yu., Rumyantsev P.O., Krylov V.V., Petrosyan K.M., Kaprin A.D., Ivanov S.A., Podvyaznikov S.O., Romanov I.S., Mudunov A.M., Slashchuk K.Yu., Zhikhorev R.S., Volkonsky M.V., Chagova R.M., Suslova I.R., Khryapa A.I., Lepshokova A.Kh., Fadeeva N.L., Safarova A.R., Kaleikina L.P., Lymar E.V., Chernyakova E.M., Snezhko O.A., Zinkovskaya A.E. ,Mufazalov F.F.,Kuzmina E.S., Druzhinina Yu.V., Musin Sh.I., Mukhitova M.R., Khasanova A.I., Safina S.Z., Kirienko S.L. Efficacy and tolerability of lenvatinib in radioiodine-resistant differentiated thyroid cancer based on the results of a multicenter observational study in the Russian Federation. Head and neck Tumors. 2020; 10(1): 65–72. (in Russian)].

2. Amaravadi R., Kimmelman A.C., White E. Recent insights into the function of autophagy in cancer. Genes Dev. 2016; 30(17): 1913–30. doi: 10.1101/gad.287524.116.

3. Yun C.W., Lee S.H. The roles of autophagy in cance. Int J Mol Sci. 2018; 19(11): 3466. doi: 10,3390 / ijms19113466

4. Gewirtz D.A. The four faces of autophagy: Implications for cancer therapy. Cancer Res. 2014; 74: 647–651. doi: 10.1158/0008-5472.CAN-13-2966.

5. Rabinowitz J.D., White E. Autophagy and metabolism. Science. 2010; 330 (6009): 1344–1348. doi: 10.1126 / science.1193497.