MICROSATELLITE-UNSTABLE COLORECTAL CANCER IN ELDERLY PATIENTS: CLINICAL FEATURES AND THE ROLE OF IMMUNODEFICIENCY

Author:

Pashkov D. V.1ORCID,Venina A. R.2ORCID,Ivantsov A. O.2ORCID,Yanus G. A.2ORCID,Raskin G. A.3,Imyanitov E. N.4ORCID,Kubrina S. E.5,Mikushina A. D.2,Manikhas G. M.6,Ponomareva E. V.7,Dzidzava I. I.8,Iyevleva A. G.9ORCID

Affiliation:

1. Medical Institute N. A. Berezin Sergey, S.M. Kirov’s Military Medical Academy

2. N.N. Petrov National Medical Research Center of Oncology

3. Medical Institute N. A. Berezin Sergey, A.M. Granov Russian Research Center of Radiology and Surgical Technologies

4. N.N. Petrov National Medical Research Center of Oncology, Saint-Petersburg State Pediatric Medical University

5. Saint-Petersburg State University

6. Saint-Petersburg Pavlov State Medical University

7. Saint-Petersburg City Clinical Oncology Centre

8. S.M. Kirov’s Military Medical Academy

9. N.N. Petrov National Medical Research Center of Oncology, Saint-Petersburg State Pediatric Medical University

Publisher

Tomsk Cancer Research Institute

Subject

Cancer Research,Oncology

Reference30 articles.

1. Hatch S.B., Lightfoot H.M.Jr., Garwacki C.P., Moore D.T., Calvo B.F., Woosley J.T., Sciarrotta J., Funkhouser W.K., Farber R.A. Microsatellite instability testing in colorectal carcinoma: choice of markers affects sensitivity of detection of mismatch repair‑deficient tumors. Clin Cancer Res. 2005 Mar 15; 11(6): 2180–7.

2. Morandi L., de Biase D., Visani M., Monzoni A., Tosi A., Brulatti M., Turchetti D., Baccarini P., Tallini G., Pession A. T([20]) repeat in the 3’‑untranslated region of the MT1X gene: a marker with high sensitivity and specificity to detect microsatellite instability in colorectal cancer. Int J Colorectal Dis. 2012 May; 27(5): 647–56. doi: 10.1007/s00384‑011‑1365‑7.

3. Piñol V., Castells A., Andreu M., Castellví-Bel S., Alenda C., Llor X., Xicola R.M., Rodríguez-Moranta F., Payá A., Jover R., Bessa X.; Gastrointestinal Oncology Group of the Spanish Gastroenterological Association. Accuracy of revised Bethesda guidelines, microsatellite instability, and immunohistochemistry for the identification of patients with hereditary nonpolyposis colorectal cancer. JAMA. 2005 Apr 27; 293(16): 1986–94. doi: 10.1001/jama.293.16.1986.

4. Vilar E., Gruber S.B. Microsatellite instability in colorectal cancer‑ the stable evidence. Nat Rev Clin Oncol. 2010 Mar; 7(3): 153–62. doi: 10.1038/nrclinonc.2009.237.

5. Boland C.R., Goel A. Microsatellite instability in colorectal cancer. Gastroenterology. 2010; 138(6): 2073–2087. doi: 10.1053/j.gastro.2009.12.064.

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