Affiliation:
1. Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Abstract
Abstract. Breast cancer is one of the most commonly diagnosed cancers worldwide. According to the World Health Organization, the incidence of breast cancer was 2.26 million in 2020, overtaking the incidence of lung cancer. In Russian Federation, the increase in new cases of breast cancer over the ten years from 2005 to 2015 was 31.76 %. Microscopic calcium deposits within breast tissue, microcalcifications, can be early signs of breast cancer. Being a significant diagnostic finding, microcalcifications allow the assessment of the extent of the disease. A detailed understanding of the morphogenesis of microcalcifications can improve knowledge about early stages of breast cancer, but there is no studies that would combine the results of the latest basic scientific research and current knowledge about their clinical significance.The aim of the study was to analyze and summarize the available data on the prognostic value of microcalcifications in patients with breast cancer.Material and Methods. A search was carried out for available literary sources published in the Medline, Elibrary, etc. databases for the period since 2015. A total of 250 sources devoted to the analysis of the morphogenesis of microcalcifications and their diagnostic value were found. Of them, 37 were included in this review.
Publisher
Tomsk Cancer Research Institute
Reference43 articles.
1. Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov; 68(6): 394–424. doi: 10.3322/caac.21492.
2. Yakobs O.E., Rozhkova N.I., Kaprin A.D., Burdina I.I., Zapirova S.B., Mazo M.L., Prokopenko S.P. X-ray negative nonpalpable breast cancer. the possibilities of current radiodiagnosis. P.A. Herzen Journal of Oncology. 2019; 8(3): 153–160. (in Russian)
3. Chernov V.I., Medvedeva A.A., Sinilkin I.G., Zelchan R.V., Bragina O.D., Skuridin V.S. Experience in the development of innovative radiopharmaceuticals at the Tomsk Research Institute of Oncology. Siberian Journal of Oncology. 2015; Suppl 2: 45–47. (in Russian)
4. Chernov V.I., Medvedev A.A., Sinilkin I.G., Zelchan R.V., Bragina O.D., Choynzonov E.L. Nuclear medicine as a tool for diagnosis and targeted cancer therapy. Bulletin of Siberian Medicine. 2018; 17(1): 220–231. (in Russian) doi: 10.20538/1682-0363-2018-1-220-231.
5. Yakobs O.E., Rozhkova N.I., Kaprin A.D. Possibilities of sonoelastography in diagnosing of the breast diseases with microcalcifications of different origin. Obstetrics and Gynecology: News, Opinions, Training. 2017; 1(15): 69–75. (in Russian)